A summary of studies – BPC-157

BPC-157 is a 15-amino acid long peptide, and a part of a naturally occurring peptide in the human stomach (BPC-157 is derived from human gastric juices). It is a signalling peptide; it signals for certain processes to take place in the body.

BPC-157 protects the body from injuries, and also helps it heal previously acquired injuries, and is currently undergoing human trials[1] . This is a list summing up most of the benefits this peptide is known to have (Source with citations) (4 of the references are not in the main source and were individually added):


Blood Pressure

  1. BPC-157 increases blood pressure in rats with low blood pressure.
  2. BPC-157 decreases blood pressure in rats with high blood pressure.

Potassium Imbalance

  1. BPC-157 protects from heart failure in a state of hyperkalemia (potassium overdose).
  2. BPC-157 protects from heart failure in a state of hypokalemia (potassium deficiency).

Calcium Imbalance

  1. BPC-157 protects rats from damage (heart failure, pancreatitis, peptic ulcers) induced by hypercalcemia (calcium overdose).
  2. BPC-157 protects rats from calcium channel blocker overdose.

Magnesium Imbalance

  1. BPC-157 protects rats from hypermagnesemia (magnesium overdose).

Wound Healing

  1. BPC-157 significantly improves healing after the following injuries: skin incisions; deep skin burns; various anastomoses as intestinal wounds; diabetic wounds; various fistulas; various tissue transections, particularly ligament, tendon, muscle and nerve. Healing time of all these injuries is significantly decreased with BPC-157 administration.
  2. BPC-157 prevents scar tissue buildup after injury, and reduces already existing scar tissue.

Immune System

  1. BPC-157 modulates the immune system activates macrophages in the immune system, which leads to increased production of growth factors that fight infections, ultimately strengthening the immune system.

NSAID side effects and toxicity

  1. BPC-157 effectively reduces the side effects and toxicity of NSAIDs, particularly gastric, intestinal, liver and brain lesions, prolonged bleeding and various behavioural disturbances – all of these are significantly antagonized by BPC-157 administration.

Alcohol intoxication

  1. BPC-157 prevents and inhibits the effect of alcohol acute intoxication, withdrawal, and acute and chronic gastric and liver lesions.

Antidepressant activity

  1. BPC-157 has antidepressant effects in rats; it reduces immobility time in a forced swimming test[2] .

Opioid system

  1. BPC-157 reduces withdrawal symptoms in morphine-addicted mice.

Dopamine system

  1. BPC-157 reduces motor abnormalities and hyperactivity induced by the dopaminergic neurotoxin MPTP.
  2. BPC-157 decreases chronic amphetamine-induced behavioral disturbances[3] .

Serotonin system

  1. BPC-157 is effective against serotonin syndrome in rats[4] .

GABA system

  1. BPC-157 significantly decreases diazepam tolerance, physical dependence and withdrawal symptoms in mice[5] .

Anti-cancer activity

  1. BPC-157 significantly prolongs survival of rats with carcinoma and melanoma B-16 cancers, from 25 days to 45+ days.

Gastric ulcers

  1. BPC-157 prevents development of gastric ulcers.
  2. BPC-157 heals existing gastric ulcers by reducing the ulcer area and accelerating the rebuilding of glandular epithelium and formation of granulation tissue.

Inflammation, pain and body temperature

  1. BPC-157 successfully reduces several models of acute, non-specific inflammation.
  2. BPC-157 acts against temperature decrease (i.e. water immersion test) and increase (yeast- induced).
  3. BPC-157 increases pain threshold in carrageenan test in rats.

Diabetes

  1. BPC-157 increases healing of skin wounds in diabetic animals.
  2. BPC-157 prevents fructose-induced high blood pressure.
  3. BPC-157 inhibits the development of insulin resistance.

Nerve injury

  1. BPC-157 improves healing of a transected sciatic nerve in rats, which is particularly shown as faster axonal regeneration.
  2. BPC-157 strongly decreases the consequences of animal brain injuries induced by a falling weight.

Antiviral activity

  1. BPC-157, given before infection of rats with hepatitis A virus, Lymphatic Choriomeningitis (LCM) virus and herpes virus types 1 and 2, completely prevented all signs of infection and disease.
  2. BPC-157 given to rats after viral infection delays onset of disease symptoms and decreases death.

All citations to the papers demonstrating the benefits mentioned in the list can be found in the source linked at the top of the list (except for 4 which are stated in the list itself).

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