The GHK-Cu is a peptide, a naturally occurring copper complex that has been first identified in the human plasma. It has also been found in different body areas, such as saliva and urine.

Copper peptides are usually small and are naturally occurring protein fragments. They have a high affinity for copper ions, and Evidence even suggests that they are critical to normal body functions. 

A lot of clinical studies have shown that GHK-Cu has different roles and benefits in the human body, including:

  • Wound healing
  • Attracting immune cells
  • It gives antioxidants and anti-inflammatory effects
  • Stimulates Collagen
  • Glycosaminoglycan synthesis in the skin fibroblasts
  • Promotes Blood Vessel Growth

Clinical Evidence has shown that GHK-Cu also acts as a feedback signal for tissue injury. Also, GHK-Cu is known to act as a potent protector of tissue and anti-inflammatory agent, which reduces oxidative damage in tissues.

Overall, GHK-Cu has been discovered to be involved in signalling tissue remodelling. This is through removing damaged/scarred tissue and generating healthy tissue. 


Copper peptide GHK-Cu and its analogues were found to stimulate hair growth strongly. The efficiency of the synthetic analogue of GHK-Cu was similar to that of 5% minoxidil.

GHK-Cu Dosage Guide | What You MUST Know

Based on the available research, GHK-Cu is considered to be safe and well-tolerated [1]. According to Dr Pickart, credited with discovering GHK-CU, “no issues have ever arisen during its use as a skin cosmetic or in human wound healing studies” [2]. That said, it is still useful to have a bit of background on the prevalent GHK-Cu dosing protocols.

Minimum effective dose

The lowest known doses of GHK-Cu administered to test subjects involve the application of skin creams and topical ointments. Skin creams containing GHK-Cu are usually applied once or twice a day to affected areas—usually to the face for skin tightening and wrinkles, to the scalp for hair growth, or other areas for scars or wound healing [10]. When administered in this manner, GHK-Cu appears to be non-toxic and non-irritating with no adverse effects [2].

When injected, there is little data to indicate the minimum effective dose of GHK-Cu [11]. Where GHK-Cu is sold as a powder reconstituted for injection, a typical starting dose is 1 mg per day over a treatment course.

Effective dose

The effective dose of GHK-CU depends on the administration route, whether via injection, a topical cream, or tablet. GHK-Cu injectionsSubcutaneous injections are a common way to administer GHK-Cu to test subjects for the purpose of studying systemic healing, skin rejuvenation, and hair growth.

Researchers and anti-ageing doctors typically administer 1-2 mg/daily of GHK-Cu throughout a 30-day treatment.

Skin creams and skin patches

GHK-Cu skin creams and patches seem to pass therapeutically effective amounts of this copper peptide through the skin and into the body [14].0.5 micrograms/kg seems to be effective as a daily dose for lowering anxiety. That would be 35 μgs for a 70kg person [15].50 mg seems adequate as a person’s daily dose for systemic healing [11].

Of course, topicals may vary in their formulas and exact GHK-Cu content, so it is always prudent to read the instructions for the product you’re using and consult your physician as necessary.

Liposomal encapsulated oral tablets.

No evidence administering GHK-Cu in traditional pill form produces any effects, as it is broken down in the intestines. However, research indicates that liposomal encapsulated tablets may be effective when dosed at 10 mg per day or more [11].

Lethal dose

GHK can lower blood pressure, so a large enough dose may have serious consequences. However, the lethal dose of GHK-Cu peptide is very high—it would be about 21,000 mg for a 70kg human (or about 330 mg/kg) [13].

Recommended dose

As a research peptide, there is no “recommended dose” for GHK-Cu. However, a review of the available literature suggests that researchers can dose it in the following way [2]:

GHK-Cu Dose: 1-2 mg per day, injected subcutaneously or intramuscularly.Frequency: Once per day. You can also split the dose into several smaller injections.

Duration of Cycle: 30 days

We do not encourage the unsupervised self-administration of GHK-Cu or any other research peptide—under any circumstances.