Growth Differentiation Factor 8 (GDF8) is a member of the transforming growth factor-beta (TGF-beta) superfamily of proteins. It plays a critical role in muscle development and growth. GDF8, also known as myostatin, is a negative regulator of muscle growth and is responsible for preventing excessive muscle growth.
What is GDF8?
GDF8 is a protein that is primarily expressed in skeletal muscle and acts as a negative regulator of muscle growth. It does this by binding to and activating the activin type II receptor, which leads to the inhibition of muscle cell proliferation and differentiation.
How does GDF8 work?
GDF8 works by binding to and activating the activin type II receptor, which leads to the inhibition of muscle cell proliferation and differentiation. This results in a decrease in muscle growth and size.
What are the potential benefits of GDF8?
The potential benefits of GDF8 include the treatment of muscle-wasting diseases, such as muscular dystrophy, and the promotion of muscle growth in individuals with muscle loss due to ageing or illness. Additionally, GDF8 may help prevent excessive muscle growth and the development of muscle-related disorders, such as hypertrophy.
What are the potential side effects of GDF8?
GDF8 is still in the early stages of research, and more studies are needed to understand its potential side effects fully. However, some studies have suggested that GDF8 may cause an increase in muscle mass and strength, but it may also cause muscle pain, cramping, and weakness. Additionally, GDF8 may also cause an increase in injury risk.
In human trials, the dosage of GDF8 has varied depending on the specific study and the research goals. The dosages used in human studies have ranged from 50 mcg to 2mg per week. Still, again, it is essential to note that any dosage used in human trials should be determined by qualified medical professionals based on factors such as the individual’s weight, overall health, and medical history. It is also important to note that self-administering GDF8 without medical supervision can be dangerous and is not recommended.
- GDF8/Myostatin. (n.d.). Retrieved from https://www.genecards.org/cgi-bin/carddisp.pl?gene=GDF8
- GDF8/Myostatin. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/gene/2651
- GDF8/Myostatin. (n.d.). Retrieved from https://www.uniprot.org/uniprot/P51154
- GDF8/Myostatin. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK56954/
Please note that GDF8 is also known as myostatin, and some research might use that name instead.