PT-141 or Bremelanotide is the generic term for a research peptide being studied for its possible use in helping to improve sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder).
Bremelanotide (PT-141) has been developed from ‘Melanotan II’, which was initially developed as a sunless tanning agent, but which was found to induce spontaneous erections. It is a synthetic melanocortin agonist, and acts within the brain, and not directly on blood vessels. Its full method of action isn’t fully understood, but is in part a dopamine agonist.
Clinical Trials. A trial published by Rosen et al in 2004 reported on inhaled PT-141. See this thread. It was administered in doses between 4mg and 20mg. Mean plasma concentrations were highest after thirty minutes, and had reduced to low levels after eight hours. Good safety was reported even at 20mg doses. The effects of PT-141 became apparent in as little is 30 minutes.
A second report by Rosen et all, in 2004, on 4mg and 6mg doses of injected PT-141 in dysfunctional patients, concluded that
“The erectile response induced by PT-141 was statistically significant at both doses. PT-141 was safe and well tolerated in both studies. The erectogenic potential of PT-141, its tolerability profile and its ability to cause significant erections in patients who do not have an adequate response to a PDE5 inhibitor suggest that PT-141 may provide an alternative treatment for ED with a potentially broad patient base.”
Purchasing and Using PT-141. There are a number of sites offering PT-141. I’ve used [edited] who delivered the day after ordering. With a £20 vial of PT-141 containing perhaps eight or ten doses it’s an inexpensive medication, – compared to, say, Vitaros.
The PT-141 is generally available in 10mg vials of freeze-dried powder, to which you add 1ml of sterile water. This is best done using a syringe to squirt the water into the vial. The powder quickly dissolves and you then fill syringes with the liquid, or fill nasal sprayer with the liquid, and keep them in a fridge. (Some reports suggest storing in a freezer is better, but if you’re only storing them for a couple of weeks it’s probably unimportant.)