Sermorelin or GRF 1-29 is a growth hormone secretagogue, which means that it stimulates the pituitary gland to produce and secrete HGH. It is a form of GRF that contains only the first 29 amino acids. GRF that is produced by neurosecretory neurons in the brain contains 44 amino acids. Only the first 29 amino acids are responsible for stimulating pituitary production and secretion of HGH. Sermorelin has highly specific receptors on pituitary somatotrophs. So it binds to the cells that produce and release HGH. Upon binding, Sermorelin acts through a cylicAMP second messenger system exactly the same as that used by naturally occurring growth hormone releasing hormone. Furthermore, it has an excellent safety profile. Its effects are regulated at the level of the pituitary gland by negative feedback and by the release of somatostatin so there are fewer safety concerns such as those associated with HGH overdosing. Tissue exposure to HGH released by the pituitary influence of Sermorelin mimics normal physiology, By stimulating the pituitary it preserves more of the growth hormone neuroendocrine axis that fails with aging, Sermorelin in a complex way, helps preserve not only youthful anatomy but also youthful physiology, it gives all of the benefits of HGH and more. Another big advantage of sermorelin is that it causes the pituitary gland to up-regulate. This stimulates the gland to rejuvenate. There are many reports in peer-reviewed medical and scientific literature showing that GRF/Sermorelin also has a direct effect on the brain to promote non-REM slow wave sleep.
What is Sermorelin Acetate?
Sermorelin(GHRH) is a bio-identical hormone that has recently been genetically engineered to stimulate the secretion of Growth Hormone Releasing Hormone (GHRH) from the hypothalamus, a gland adjacent to the pituitary gland.
GHRH is a peptide that contains the first 29 amino acids of our own GH. These 29 amino acids are the active amino acids of GHRH. It is GHRH that stimulates the pituitary glands to release GH. As we get older, the hormones produced by the anterior pituitary are depleted. It has now been shown that GHRH can restore the GH-RNA to a youthful level causing elevation of levels of IGF-1.