TB-500 Fact sheet for pets

What is TB-500?

TB-500 is a peptide which is applied by subcutaneous injection to promote angiogenesis, wound healing muscle growth. It has demonstrated cardioprotective and immune-potentiating effects, as a potent anti-aging, and has anti-scarring properties.
TB-500 is a synthetic version of the naturally occurring peptide present in virtually all human and animal cells first located in the Thymus gland in 1981.

The potency of Thymosin Beta 4 present in TB-500 is approximately 99%, the highest of its kind.

How does TB-500 Work?

In angiogenesis and in wound healing, TB-500 acts by accelerating the migration of blood vessel cells and skin cells and increasing the production of extracellular matrix-degrading enzymes.
It has also been shown to stimulate epidermal stem cell differentiator. When applied by subcutaneous injection, it assists in the generation of new blood vessels and aids wound healing by promoting skin cell regeneration.

How does TB-500 Work Scientifically?

One of TB-500 4’s key mechanisms of action is its ability to regulate the cell-building protein, actin, a vital component of cell structure and movement. Of the thousands of proteins present in cells, actin represents up to 10% of the total proteins which therefore plays a major role in the genetic makeup of the cell.

This potent peptide is a member of the ubiquitous family of 16 related molecules with a high conservation of sequence and localization in most tissues and circulating cells in the body. TB-500 not only binds to actin but also blocks actin polymerization and is the actin-sequestering molecule in Eukaryota cells.

TB-500 was identified as a gene that was up-regulated four to six-fold during early blood vessel formation and found to promote the growth of new blood cells from the existing vessels.

This peptide is present in wound fluid and when administered subcutaneously, it promotes wound healing, muscle building, decreases recovery time of muscles fibers and their cells.

An additional key factor of TB-500 is that it promotes cell migration through a specific interaction with actin in the cell cytoskeletal. It has been demonstrated that a central small amino acid long actin-binding domain has both blood cell reproduction and wound healing characteristics. These characteristics are uncovered by accelerating the migration of endothelial cells and keratinocytes. It also increases the production of extracellular matrix-degrading enzymes.

TB-500 is different from other repair factors, such as growth factors, in that it promotes endothelial and keratinocyte migration. It also does not bind to the extracellular matrix and has a very low molecular weight meaning it can travel relatively long distances through tissues.

The Product

TB-1000 is different from other repair products in that it promotes blood vessel cell and skin cell regeneration and migration, thus assisting rapid repair and healing. Because it promotes skin cell regeneration it has also shown evidence of anti-scarring properties.

Benefits of TB-500

In performance animals, as in all animals, the benefits include faster and better wound repair and faster recovery from injury. Trials to date indicate faster recovery time (wear and tear) from training, increased muscle girth, increased muscular endurance, increased muscular strength and increased energy levels.

What does TB-500 Achieve?

Whether you’re in performance or competition or simply a cherished pet, TB500 provides rapid surface wound healing with little or no scarring and minimal discomfort. If the animal experiences wound injury, it will benefit from TB-500.
As TB-500 heals it at the cellular level, it is natural and rapid. Stem cells play an integral part in wound healing and regeneration of body organs and tissue at the cellular level.

Can All Animals Benefit?

All mammalian animals can benefit from the use of TB-500. Whether an animal is large or small, a performance animal, a breeding animal or a loved and valued pet, TB-1000 can assist in rapid wound healing and blood vessel regeneration. TB-1000 is known to help diabetes in dogs.

Is TB-500 Safe?

As TB-500 is a synthetic version of the naturally occurring peptide found in all animal cells, it does not pose as a foreign substance to the animals’ body. When used within the recommendations of this fact sheet, TB-500 is completely safe.

Side Effects?

TB-1000 is a naturally occurring peptide promoting the repair and regeneration of skin and blood vessels. It is completely Drug and Chemical free. There are no side effects with the use of this product. It does not swab.

Is it Legal for Performance Animals?

TB-500 is 100% drug and chemical free. If used according to directions for use, it will not compromise any performance animal in any event or race in which it competes. IT DOES NOT SWAB.

Sizes & Availability?

TB-500 is available in boxes of 6 x 20 ml vials. Each vial contains 20 mL of Thymosin Beta 4 peptide.

How is it Administered?

TB-500 is administered by way of subcutaneous injection. It can be applied by any competent person, however, it is preferably administered by a qualified veterinarian.

How often can it be used?

It is recommended TB-500 is used in accordance with the dosages stated in this fact sheet.

Directions for Use Storage

TB-500 should be stored at room temperature. Do not expose to sunlight. Keep out of reach of children.


Do not use if the security seal is broken or missing. Do not use after the expiration date of the vials? Used vials do not contain any toxic products and can be disposed of safely.


Large Animals – 2mL (1 vial / week for 6 weeks) Small Animals – 1mL (half vial) / week for 6 weeks ADD 2mL of the provided saline solution to the compound. Add saline at an angle, expelling along the inside wall of the vial. The compound will be dissolved immediately. Do not add the saline directly on the compound.

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