Ipamorelin is in the category of drugs known as GH secretagogues. This category of drugs includes GHRP-2, GHRP-6, Ipamorelin, and Hexarelin. Its primary function is to stimulate the pituitary gland to produce more growth hormone. Like the other GHRPs, it has a 2-fold mechanism of action, in that it causes an increase in GH through amplifying the natural growth hormone releasing hormone (GHRH) signal transduction pathway, as well as by suppressing the actions of Somatostatin.
Ipamorelin is a 3rd generation GHRP which displays great selectivity in its actions. Ipamorelin will not lead to any degree of appetite stimulation, will not affect prolactin or cortisol, and is used solely for GH release. On a mcg to mcg basis, its strength is comparable to GHRP-6, but unlike GHRP-6, it can be dosed much higher, resulting in potentially greater elevations in GH. Similar to GHRP-2, IPA has no ceiling dose. Therefore, as the dosage of IPA is titrated upward, GH release will continue to rise accordingly. Ipamorelin has developed a reputation as the “cleanest” of the GHRP’s and rightfully so.
Common benefits of GH (Ipamorelin) include:
- Decreases in body fat
- An increase in lean mass
- Increased collagen production
- Improved sleep
- Increased cellular repair
- An increase in IGF-1
- Increases in bone density
- Common side effects of GH (Ipamorelin) include:
- Water retention
- Tightness and/or carpel tunnel-like symptoms
- Numbness and tingling in the extremities
- A decrease in insulin sensitivity
How does it Work?
After an athlete administers Ipamorelin, a selective pulse is sent that stimulates the hypothalamus/pituitary to release GH. This pulse can endure for approximately three hours after injection. Once the GH pulse is sent, the cells go directly to the muscle to support development while staying clear of any possible bone or cartilage growth. This is good for Ipamorelin users, as long term usage will effect lean body muscle growth without the possibility of experiencing any bone or cartilage deformities. The same cannot be said for synthetic HGH users, who experience pronounced side effect in swelling joints and even in some cases Carpal Tunnel. Ipamorelin will increase cell synthesis, elevate secretion levels of insulin from pancreatic tissue, and increase ghrelin in the stomach – which helps release GH and control hunger. All of these functions work to promote fat loss, shuttling of nutrients, and building lean muscle mass.