Recent studies revealed that the rodents displayed increased food consumption and body weight. GHRP-2 plays a crucial role in accentuating the release of ghrelin. There is enough data to prove that the peripheral administration of the peptide promotes lean muscle protein and increases food intake and in most cases, muscle development is possible. GHRP-2 enhances the production of growth hormone from the somatotropes on the anterior lobe of the pituitary gland. Hormonal regulation of food intake can be divided into long term and short term fat storage signals which include leptin and insulin, the short term include Ghrelin ,cholecystokinin , and PYY. Ghrelin is a peptide that is secreted on the walls of the stomach and it acts on the NPY-AGRP neurons, and it activates in the arcuate nucleus.
Peptide and Ghrelin
One of the most important aspects to consider in peptide research is an ongoing process and the mechanism of how the hormones circulate and how they reach the hypothalamic neurons is still unclear. The research on rodents indicated that centrally administered ghrelin acts on the growth hormone secretagogues and this stimulates food intake. There is evidence that it has spontaneous variation in the endogenous amounts of ghrelin and this may play a role in diurnal meal times. In addition, postprandial suppression of the ghrelin hormone is equal to the size of the meal taken.
Scientific data indicated that the peptide and ghrelin can elicit anorexic properties and can cause an acute change in food taken in humans. Although the conclusion of GHRP-2 activity has not been seen more results are indicating the possibility of having the same. The alteration of ghrelin has a huge magnitude on the kind of downstream effects it occurs through nervous and peripheral receptors. Studies revealed that the peptide may be used in the future to treat various conditions. However, it is important to note that research is still ongoing and the peptides have not been approved for human consumption. All the peptides are for research purposes only.
GHRP-2. CJC 1295 and GHRP-2 are closely related because of their action of activating ghrelin. Ghrelin increases energy consumption, gastric emptying, and feeling of hunger. This has a positive feedback mechanism in stimulating the release of growth hormone from the anterior lobe of pituitary gland. A combined vial of the peptide has shown increased potency and effectiveness. GHRP-2 and CJC 1295 are capable of stimulating and creating a larger pulse on the GHRH with a consistency and predictability to maintain hormone level at an optimal level.
Studies revealed that growth hormone has lipolysis process while inhibiting lipogenic activities which is the deposition of fats in the peripheral and visceral organs. Synergistic functions of CJC 1295 and GHRP-2 help in enhancing the release of growth hormone per cell.